SciELO - Scientific Electronic Library Online

vol.49 issue1Sildenafil monotherapy in patients with severe pulmonary hypertension author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




  • Have no cited articlesCited by SciELO

Related links

  • Have no similar articlesSimilars in SciELO


Revista Cubana de Medicina Militar

Print version ISSN 0138-6557On-line version ISSN 1561-3046


PEREZ RODRIGUEZ, Sonia; BARRERO VIERA, Laura; TAMAYO RODRIGUEZ, Maura  and  DAVID BALDO, Marlene. Ophthalmologic evaluation of patients with diabetic foot ulcer. Rev Cub Med Mil [online]. 2020, vol.49, n.1, e427.  Epub Mar 01, 2020. ISSN 0138-6557.


The prevalence of diabetes gradually increases worldwide and with it, the risk of microvascular complications such as diabetic retinopathy. The risk of blindness is reduced with stable metabolic control, early diagnosis and adequate treatment.


To compare the result of the ophthalmological examination performed before starting treatment with Heberprot-P, with that performed five months after initiation, at different doses.


A retrospective observational study was conducted in 77 patients included in four clinical trials of Heberprot-P. Analysis of the ophthalmological examination variables before and after treatment, type of diabetes and years of evolution were performed.


Prevalence of type 2 diabetics was observed with respect to type 1 in an 11: 1 ratio, with an average of 16.3 years of diabetes evolution. Half of the patients had nonproliferative diabetic retinopathy, predominantly of the mild form, in the examination performed before treatment with Heberprot-P. Only one elderly patient with other comorbidities developed a proliferative diabetic retinopathy, after a previous examination in which non-proliferative diabetic retinopathy and diabetic macular edema were observed.


The appearance or progression of diabetic retinopathy is uncommon in complicated patients with diabetic foot ulcer treated with Heberprot-P, up to five months after treatment.

Keywords : diabetes mellitus; diabetic retinopathy; diabetic angiopathy; Heberprot-P.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )