Abstract

BLANCO HIDALGO, Odalys et al. Antibacterial effect of Surfacen and surfactant protein A (SP-A) against a clinical isolate of Streptococcus pneumoniae. Rev Salud Anim. [online]. 2014, vol.36, n.1, pp.48-52. ISSN 0253-570X.

Surfacen^®, a clinical preparation of exogenous pulmonary surfactant, and pulmonary surfactant protein A (SP-A) were evaluated in relation to their in vitro effect on the growth of a clinical isolate of Streptococcus pneumoniae. The bacterium was incubated in a normal saline solution for 5 h at 37^oC, together with Surfacen^® and SP-A. Surfacen^® showed antibacterial activity against the clinical isolate of Streptococcus pneumonia at 10 or 25 mg/ml with one logarithm of reduction of the bacterial growth; also SP-A had the same effect at concentrations of 0.25, 0.5 or 1 mg/ml. Porcine SP-A addition at the highest Surfacen^® concentration (25 mg/ml) showed a higher antibacterial activity by reducing two logarithms of bacterial growth.

Keywords : lung surfactant; Surfacen^®; antibacterial; Surfactant Protein A (SP-A); Acute Respiratory Distress Syndrome.

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