Resumo

DE ARMAS, Elizabeth et al. In vitro antiviral activity of Rhizophora mangle L. aqueous bark extract and the butanolic fraction against Canine Distemper Virus and Bovine Herpes Virus type 1. Rev Salud Anim. [online]. 2018, vol.40, n.1, pp. 00-00. ISSN 2224-4700.

There is currently an increasing need for new substances or secondary metabolites from natural products with antiviral activity. The aim of this study was to determine the antiviral activity of Rhizophora mangle L. against DNA and RNA virus. With this aim, R. mangle aqueous bark extract (RMABE) and its butanolic fraction (BF-RMABE) were evaluated for the cytotoxicity and cytopathic effect inhibition assay. The selectivity index was also calculated. An in vitro antiviral activity was demonstrated for RMABE and BF-RMABE against the RNA prototype of Canine Distemper Virus (CDV) (CI₅₀ 83.30 and 86.10 μg/mL, respectively) and the DNA prototype of Bovine Herpes Virus type 1 (BHV-1) (CI₅₀ 87.50 and 90.63 μg/mL, respectively). The results showed the promising antiviral effect of the evaluated R. mangle extracts, suggesting the need for further tests to confirm itsin vivo activity.

Palavras-chave : in vitro antiviral activity; CDV; VHB-1; polyphenols; Rhizophora mangle.

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