Revista Cubana de Medicina Tropical
versión On-line ISSN 1561-3054
DIAZ GONZALEZ, MANUEL et al. Inmunogenicidad de la vacuna Heberbiovac-HB en niños. Rev Cubana Med Trop [online]. 1996, vol.48, n.3, pp. 195-199. ISSN 1561-3054.
The Cuban recombinant vaccine against heaptitis B virus was applied with doses of 10 ìg to children under 15 in a scheme from 0, 1 to 6 months. The immunogenecity was evaluated at 2, 7, and 12 months and showed 100 % of seroconversion with protective titres. 65.9, 100, and 83.5 % of the vaccinated attained titres higher that 100 UI/L at 60, 210, and 360 days. The geometrical mean was of 213.6, 8208.2, and 568.0 UI/L, respectively. All the groups obtained 100 % of seroconversion; however, there were significant differences (p < 0.05) in favor of the preschool and school children compared with those over 10 as regards the response level (titres higher than 100 UI/L) and the geometrical mean of antibody titres in the 3 samples. It was demonstrated the high immunogenic power of the vaccine at these ages, which makes it recommendable for their protection against the hepatitis B virus (HBV).
Palabras llave : HEPATITIS B VACCINES [immunology]; VACCINES, SYNTHETIC [immunology]; HEPATITIS B ANTIBODIES [blood]; CHILD.