Abstract

PEDROSO FLAQUET, PLÁCIDO; DIAZ GONZALEZ, MANUEL; RODRIGUEZ LAY, LICEL  and  BRAVO GONZALEZ, RAMÓN. Inmunogenicidad de la vacuna Heberbiovac-HB en ancianos. Rev Cubana Med Trop [online]. 1996, vol.48, n.3, pp.200-203. ISSN 0375-0760.

The Cuban recombinant vaccine against the hepatitis B virus was applied to a group of individuals over 65 from a geriatric home in Havana City. Dose of 20 ìg were administered within a scheme from 0.1 to 6 months in order to study its immunogenecity, which was evaluated at 2,7, and 12 months after the first dose. 47.1 % of protective titres and geometrical mean of 6.04 UI/L were obtained after 60 days. 100 % of seroconversion ( UI/L) and seroprotection (10 UI/L) and geometric mean of 136.93 UI/L were obtained when the immune response was evaluated on the 7th month. Finally, after a year, seroconversion and seroprotection were also of 100 %, and the geometric mean was of 204.61 UI/L. It was proved the high immunogenic power of this vaccine, which makes it recommendable to protect this age group from the hepatitis B virus.

Keywords : HEPATITIS B VACCINES [immunology]; VACCINES, SYNTHETIC [immunology]; HEPATITIS B ANTIBODIES [blood]; AGED.