Abstract

LOBAINA BARTHELEMY, Leonor et al. Caracterización biológica de aislamientos de VIH-1 en pacientes con una evolución clínica rápida. Rev Cubana Med Trop [online]. 1998, vol.50, n.2, pp.96-99. ISSN 0375-0760.

The biological characteristics of 11 HIV-1 strains isolated from patients with a fast clinical evolution to AIDS were studied. The viral isolates were classified according to their replication kinetics and cell tropism. Taking into account these criteria, it was observed that 8 of the isolated strains (72,7 %) were of rapid high growth (RH) or slow low 3 (SL3) with preferential tropism to the lymphocytic stock, as it corresponds to AIDS patients. 3 (27,3 %) had characteristics of slow low 1 (SL1). The cytopatogenecity of the strains was studied in the MT4 celular line, and it was observed that most of them (72,7 %) were syncytium-inducing strains (SI), which allowed to prove the in vivo and in vitro relation of the biological properties. It was not so in 3 of the cultures (27,3 %) that behaved as non-syncytium inducers.

Keywords : HIV-I [isolation & purification]; HIV-1 [genetics]; ACQUIRED IMMUNODEFICIENCY SYNDROME [virology]; PHENOTYPE.

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