Resumen

GONZALEZ-GRIEGO, Martha de J. et al. Estudio comparativo entre diferentes esquemas de administración de 2 dosis con la vacuna cubana antihepatitis B. Rev Cubana Med Trop [online]. 1998, vol.50, n.3, pp.218-220. ISSN 0375-0760.

A controlled clinical trial, corresponding to stage 2, was conducted in a population of sound adult males aged 18-23 to evaluate the immunogenecity of 5 schedules of Cuban vaccine against hepatitis B (Cheberbiovac-HB). 5 groups were studied: I (control group 0, 1 and 6 months), II (0 and 2 months), III (0 and 4 months), IV (0 and 6 months), and V (0 and 8 months). The results showed no significant differences as regards the percentaje of seroprotection of any of the groups of 2 doses compared with the control of 3 doses. It is concluded that between the first and the second dose there may be a period of time from 2 to 6 months with no need to reinitiate the schedule. This information will serve as a basis for a population based study to determine which schedule is the best to be used.

Palabras clave : HEPATITIS B VACCINES [administration & dosage]; IMMUNIZATION SCHEDULE; CONTROLLED CLINICAL TRIALS; CUBA.

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