SciELO - Scientific Electronic Library Online

 
vol.51 issue1Evaluación de la prueba de la pirazinamidasa para la determinación de la susceptibilidad de Mycobacterium tuberculosis a la pirazinamidaDiagnóstico de un brote de infección respiratoria aguda en niños menores de 3 años en Santiago de Cuba author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

  • Have no cited articlesCited by SciELO

Related links

  • Have no similar articlesSimilars in SciELO

Share


Revista Cubana de Medicina Tropical

Print version ISSN 0375-0760On-line version ISSN 1561-3054

Abstract

PIMENTEL TURINO, Tamara; MARTINEZ MACHIN, Gerardo  and  GONZALEZ MIRANDA, Mario. Determinación de la concentración mínima inhibitoria de fluconazol frente a Cryptococcus neoformans. Rev Cubana Med Trop [online]. 1999, vol.51, n.1, pp.55-57. ISSN 0375-0760.

The minimum inhibitory concentration of fluconozole was determined in 36 strains of Cryptococcus neoformans var. neoformans by a casitone broth microdilution method, taking into account that it is one of the most used antifungal agents in our country for the treatment of cryptococcal meningitis, the second opportunistic mycosis in order of frequency and that with the highest lethality among AIDS patients. The minimum inhibitory concentration of the studied strains ranged 0.125 to more than 64 µg/mL for a geometrical mean of 2.38 µg/mL. 50 % of the strains were inhibited with 4 µg/mL and the least concentration that inhibited 90 % was 16 µg/mL. It is stressed the importance of continuing this type of in vitro studies to detect the appereance of resistance of C. neoformans to antifungal agents.

Keywords : FLUCONAZOLE [analysis]; CRYPTOCOCCUS NEOFORMANS [isolation & purification]; MICROBIAL SENSITIVITY TESTS.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License