Resumo

CASTANO OSORIO, Jhon Carlos; MARCET SANCHEZ, Ricardo; COX IRAOLA, Raymundo  e  SARRACENT PEREZ, Jorge. Inhibición de la invasión y multiplicación de Toxoplasma gondii en células epiteliales de colon humano por un anticuerpo monoclonal contra la proteína SAG2. Rev Cubana Med Trop [online]. 2001, vol.53, n.3, pp. 161-169. ISSN 1561-3054.

By an bromodeoxyuridine (BrdU) incorporation assay, it was proved hat an IgG1 subclass, murine monoclonal antibody to surface protein SAG2 of Toxoplasma gondii is capable of reducing the invasion and multiplication of the parasites in highly differentiated mucine secretory HT29-18N2 line cells from a human colon adenocarcinoma. This result shows the importance of surface protein SAG2 of T.gondii in invasion and further multiplication of parasites in the host cell.

Palavras-chave : TOXOPLASMA [growth & development]; BROMO-DESOXYURIDINE; ANTIBODIES, MONOCLONAL; MEMBRANE PROTEINS; ANIMALS,LABORAROTY; MICE, INBRED BALB C [immunology]; EPITHELIAL CELLS; TOXOPLAS-MOSIS; COLONIC NEOPLASMS.

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