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vol.57 issue1Use of diafiltration in the lavage of cultures of Leptospira interrogans canicola canicola for the production of vaccine vax-SPIRALIsolation of a strain from the Bataviae pathogenic complex in patient vaccinated against copenhageni, canicola and mozdok author indexsubject indexarticles search
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Revista Cubana de Medicina Tropical

Print version ISSN 0375-0760On-line version ISSN 1561-3054


BENITEZ ZAMORA, José Daniel et al. Scale-up of the fermentation of Leptospira interrogans canicola canicola for the production of vax-SPIRAL vaccine. Rev Cubana Med Trop [online]. 2005, vol.57, n.1, pp.71-72. ISSN 0375-0760.

The operational conditions for the production of vaccine vax-SPIRAL were established at the scale of 100 L. It was concluded that it should be carried out with an air flow of 10 L/min (0.1 vvm) and without mechanical agitation.

Keywords : Vax-SPIRAL; fermentation; leptospirosis.

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