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Revista Cubana de Medicina Tropical

versión impresa ISSN 0375-0760versión On-line ISSN 1561-3054

Resumen

MARTINEZ MOTAS, Isabel et al. Characterization of Neisseria meningitidis strains isolated from carriers in Cuba during 20 years. Rev Cubana Med Trop [online]. 2006, vol.58, n.2. ISSN 0375-0760.

The epidemiological markers of Neisseria meningitidis strains isolated from carriers in Cuba for 20 years (1982-2002) were investigated. There were identified the serogroups, serotypes, subtypes and immunotypes of 331 strains corresponding to 2 different stages: epidemic (1982-1992) and postepidemic (1993-2002). A predominance of serogroup B (67.62 %) and of non-groupable strains (32.28 %) was observed in the epidemic stage, whereas the non-groupable strains (79.65 %) and the serogroup B (17.26 %) (p<0,05) prevailed in the postepidemic stage. This study is the first and the only one up to now that investigates Neisseria meningitidis strains isolated from carriers before and after a national mass campaign of immunization with VA-MENGOC-BCÒ (Cuban antimenigococcal vaccine against the serogroups B and C). The results obtained offered valuable data to the study, prevention and successful control of the meningococcal disease in Cuba, as well as to the development and evaluation of this vaccine.

Palabras clave : Neisseria meningitidis; asymptomatic carriers; epidemiological markers; phenotypes; antimeningococcal vaccine.

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