Revista Cubana de Medicina Tropical
versão On-line ISSN 1561-3054
GARCIA, Gissel et al. Serum nitric oxide in Macacus irus monkeys inoculated with dengue virus . Rev Cubana Med Trop [online]. 2008, vol.60, n.1, pp. 0-0. ISSN 1561-3054.
OBJECTIVE: To determine the action of nitric Oxide (NO) in serum samples of dengue 2 inoculated Macacus irus monkeys as primary infection and in dengue 4 -dengue 2 inoculated monkeys as secondary infection, taking into account that preexisting antibodies in secondary dengue infection elicit the action of antiviral molecules such as nitric oxide. METHODS: NO levels referred as nitrite levels were detected by Griess colorimetric reaction. RESULTS: The highest nitric oxide levels were detected in those animals with primary infection seven days after inoculation monkeys whereas those monkeys with secondary infection did not show NO levels over 100 µM. CONCLUSIONS: Our results suggest that there seems to be a relationship between secondary infection and NO production inhibition.
Palavras-chave : Monkeys; dengue; nitric oxide.