Resumen

SOSA CABRERA, Tayde J.; ALVAREZ VERA, Mayling; BLUM DOMINGUEZ, Selene del Carmen  y  SALICORREA ORTEGON, Hilda. Identification of dengue virus serotypes circulating in Campeche state, Mexico. Rev Cubana Med Trop [online]. 2008, vol.60, n.3. ISSN 0375-0760.

BACKGROUND: at present, dengue is an arbovirosis that is greatly affecting the Latin American countries, and Mexico is not the exception, where a hypoendemic region has evolved into a hyperendemic area because of the circulation of multiple serotypes. OBJECTIVES: to determine the seroprevalence of dengue virus in Campeche state, Mexico, and to identify the circulating serotypes in its various municipalities. METHODS: inhibition ELISA and plate reduction neutralizing test were the methods used in this study. RESULTS: of 600 samples, 67.5 % (405) had IgG antibodies to dengue virus whereas 32.5 % (195) were negative. Regarding the serotypes, 32.3 % had primary infection with serotype DEN-1 and 68 % showed secondary infection; the prevailing sequence was DEN-1/DEN-2 and DEN-3/DEN-4 in 9 municipalities. The infection with the 4 serotypes was mostly found in the 21-30 y age group. The most circulating serotype was DEN-1 throughout the state. CONCLUSIONS: seroprevalence and frequency of secondary infection observed in children and adults indicated an increased circulation of virus in the state and this was considered an important epidemiological factor for the emergence of outbreaks and the most severe forms of the disease.

Palabras clave : Dengue; serotypes; Mexico.