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Revista Cubana de Hematología, Inmunología y Hemoterapia

versión impresa ISSN 0864-0289versión On-line ISSN 1561-2996

Resumen

ALPIZAR OLIVARES, Yulién. Penicillin and its derivatives as immune response unleashing agents. Rev Cubana Hematol Inmunol Hemoter [online]. 2000, vol.16, n.2, pp.99-104. ISSN 0864-0289.

The use of penicillin and its derivatives very often brings about hypersensitivity reactions. To characterize them, we studied the chemical structure of these antibiotics and their influence on such reactions. There are factors that may predispose people to the development of these adverse reactions, among them are the great heterogeneity in restriction by the main histocompatibility system, the phenotype of reactive cell clones to these drugs and the pattern of cytokines that are released. All the above-mentioned gives rise to the so diverse clinical picture of the reactions caused by these drugs. Widening of knowledge on mechanisms leading to these reactions becomes a challenge for researchers in the field of immunology

Palabras clave : PENICILLINS [adverse effects]; HISTOCOMPATIBILITY; ALLERGY AND IMMUNOLOGY.

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