Resumen

VILLAESCUSA BLANCO, Rinaldo et al. IgG subclasses alterations found in patients with sickle cell anemia. Rev Cubana Hematol Inmunol Hemoter [online]. 2001, vol.17, n.3, pp.189-193. ISSN 0864-0289.

A single radial immunodiffusion method was used to quantify IgG1, IgG2, IgG3 and IgG4 levels in a group of 46 patients with sickle cell anemia (hemoglobin SS) in basal state; 21 of them had no clinical complications and 25 had clinical complications refering to number of infections, melleolar ulcers, vasocclusive, hepatic and aplastic crises. One year before the blood-sample taking was set as the limit. A significant increase of IgG1 and IgG2 was observed in patients with clinical complications compared with the rest of patients and the normal controls. There was a significant correlation between the number of vasocclusive crises and the IgG1, IgG2 and IgG4 concentrations. Our results show the possibility that some inflammatory phenomena, which might persist in patients with sickle cell anemia in basal state- mainly in those with a history of clinical complications-, could cause an increased synthesis of IgG1 and IgG2

Palabras clave : IGG [analysis]; ANEMIA [complications]; IMMUNE SYSTEM [abnormalities].

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