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Revista Cubana de Hematología, Inmunología y Hemoterapia

versión impresa ISSN 0864-0289versión On-line ISSN 1561-2996


HERNANDEZ RAMIREZ, Porfirio et al. Transplant of autologous stem cells in the ischemic lower limb of a patient with severe arteriosclerosis obliterans. Rev Cubana Hematol Inmunol Hemoter [online]. 2005, vol.21, n.1. ISSN 0864-0289.

The case of a 72-year-old male patient that was hospitalized due to intense rest pain in the right lower limb and ischemic necrosis of the third and fourth toes tending to extend to the fifth toe and the back of the foot is presented. The angiographic study evidenced an occlusion of the popliteal artery at the level of its proximal segment. No improvement was attained with the usual treatment and the rest pain progressively increased. Therefore, there were criteria for a major amputation. Under these conditions, it was used the new method of cellular therapy by the implantation of mononuclear cells of his bone marrow in the ischemic lower limb. After 72 hours, a marked improvement of the pain, the edema, the skin temperature and the erythrocyanosis was observed and it was not necessary the amputation of the ischemic limb. The evaluation carried out at 4 and 24 weeks showed a significant improvement of the clinical state and of the functional tests. This case serves as an example of the advantages the treatment with autologous adult stem cells may have in the management of patients with chronic ischemia of the lower limbs and its contribution to reduce the need of amputation of the ischemic limbs.

Palabras clave : stem cells; arteriosclerosis obliterans; cellular therapy; angiogenesis.

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