Resumen

HERNANDEZ RAMIREZ, Porfirio. Regenerating medicine related to the stem-cells and its mechanisms of action from adults cells. Rev Cubana Hematol Inmunol Hemoter [online]. 2009, vol.25, n.1. ISSN 0864-0289.

Regenerating medicine is a branch of Medicine very developed in past years. Advances in this field have been closely linked with the new knowledge achieved on stem-cells and its ability to become in cells of different tissues. This type of medicine is based on the behaviors adopted by organism to substitute those damaged cells by the healthy ones by different processes in specific tissues. Therapeutic measures used may include the stem-cell transplantation, the use of soluble molecules, genic therapy and tissues engineering. Nowadays, the more used method is the adult stem-cells. However, is not well known the mechanisms by which the transplanted cells could to improve or to promote the tissue regeneration. To explain these mechanisms some hypotheses has been proposed including the cellular trans-differentiation, cells fusion, and the effects secondaries to cells release by cells of different soluble molecules with specific actions; in addition to the autocrine and paracrine effects that may have these soluble factors, it is suggested too the existence of a telecrine action. It is probable that more than one of these mechanisms be executed.

Palabras clave : Regenerating medicine; stem-cells; genic therapy; tissues engineering; paracrine effect..

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