Revista Cubana de Hematología, Inmunología y Hemoterapia
versão On-line ISSN 1561-2996
SOCARRAS FERRER, Bertha Beatriz et al. The B-CD5+ chronic lymphoid leukemia related to the phenotype expression. Rev Cubana Hematol Inmunol Hemoter [online]. 2009, vol.25, n.1, pp. 0-0. ISSN 1561-2996.
CD5 and CD6 molecules have a co-stimulant function and show homology in structure. We assessed CD6 molecule expression using anti-CD6 (T1) monoclonal antibody in the cellular immunophenotyping from patients presenting B chronic lymphoid leukemia, and it was compared to CD5 molecule expression. Results show a homology in phenotype expression of both molecules (CD5 and CD6), what associated with the fact that both lymphocyte receptors are physically linked, allow to suggest that CD6 molecule is a interesting biological marker in prognosis assessment, and the possibility of new therapeutic variants in this disease.
Palavras-chave : CD5 and CD6 molecules; LLC-B- CD5+; flow cytometry..