Revista Cubana de Hematología, Inmunología y Hemoterapia
versão On-line ISSN 1561-2996
GUERREIRO HERNANDEZ, Ana M. et al. Detection of anti-gliadin and anti-transglutaminase antibodies in patients with possible celiac disease. Rev Cubana Hematol Inmunol Hemoter [online]. 2010, vol.26, n.2, pp. 28-32. ISSN 1561-2996.
Celiac disease is an autoimmune entity with inflammatory processes in small intestine. It is caused by ingesta of gluten protein fraction in the diet of subjects with genetic predisposition subjects and has different ways of presentation including the symptomatic, typical or atypical and silent type. The detection of autoantibodies with diverse specificities must to be considered as essential in all those patients where there is predominance of digestive symptoms and nutritional affections without to rule out other atypical symptomatologies including the growth and development retard. The objective of present paper was to study the presence of anti-gliadin and anti-transglutaminase in serum of 110 patients presenting with celiac disease and it was possible to detect antibodies in 23 patients: 11 with anti-gliadin and anti-transglutaminase and a positive biopsy; 6 with positive anti-gliadin, negative anti-transglutaminase and a positive biopsy, negative anti-transglutaminase and also a negative biopsy.
Palavras-chave : Celiac disease; anti-gliadin antibodies; anti-transglutaminase antibodies.