Resumen

MACIAS-ABRAHAM, Consuelo; VILLAESCUSA-BLANCO, Rinaldo; HERNANDEZ RAMIREZ, Porfirio  y  BALLESTER-SANTOVENIA, José M.. Experience in development and application of Immunology in the past 10 years. Rev Cubana Hematol Inmunol Hemoter [online]. 2011, vol.27, n.1. ISSN 0864-0289.

Authors showed the results achieved in immunological researches in the Institute of Hematology and Immunology during past 10 years. The main basic researches are described in relation to the study of adhesion molecules under physiological and pathological conditions like in the case of the acute coronary syndrome and the drepanocythemia (D). The papers related to the immunological diagnosis of lymphoproliferative syndromes are refered which provide data to the immunoepidemiology of malignant hemopathies, specially in its phenotypic characteristics; the features of more interest in the study of the D, e.g. the decrease of levels of anti-band 3 natural antibodies in patients with vaso-occlusive crisis and its possible participation in the phenomenon of vaso-occlusion, as well as the significance of adhesion molecules in its etiopathogenesis. The results from the study of antibodies detection to PML/RARa fusion protein in the promyelocyte leukemia and its possible usefulness as marker of cellular differentiation from the presence or absence of fusion protein in the leukemic cell are described. The results achieved have contributing very much to development of Immunology in Cuba and will become standard for the future development of the specialty.

Palabras clave : Immunology; immunophenotypic process; immunodeficiencies; antibodies; molecules.

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