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Revista Cubana de Hematología, Inmunología y Hemoterapia

versión impresa ISSN 0864-0289


DE LA GUARDIA PENA, Odalis; USTARIZ GARCIA, Catalino; GARCIA GARCIA, María de los Ángeles  y  MORERA BARRIOS, Luz. Some clinical applications of zinc and its effect on the immune system. Rev Cubana Hematol Inmunol Hemoter [online]. 2011, vol.27, n.4, pp.367-381. ISSN 0864-0289.

Zinc is a chemical element located in group 12 of the periodic table; it is classified as a transition metal. From the biological point of view, it is a constituent of more than 300 metalloproteins and more than 2 000 transcription factors. Its participation in metabolism encompasses a wide variety of reactions, both synthesis and degradation of almost all biomolecules. The recommended daily intake is estimated to be between 10 and 20 mg. It is very abundant in red meat, seafood, germ of cereal and milk. It is found in virtually all cells, although 90 % of total body zinc is contained in skeletal muscle and bone. It highlights the lack of reserves and their levels are under tight homeostatic control. Due to its immune modulatory function, it has been clinically used in pediatric acute respiratory infections and immune system recovery of malnourished children. It has been used in acute diarrheal disease as a stabilizer of intestinal epithelium and membranes, as well as lipid peroxidation protector. Another of its actions is to improve healing, so it has been used in lower limb ulcers associated with venous disease and diabetic foot, which is combined its healing effect with its stimulating cellular immunity. Some skin disorders such as common warts have been treated with zinc. No papers directly relating zinc with immune compromised patient were found.

Palabras clave : Zinc; immune; immune system.

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