SciELO - Scientific Electronic Library Online

 
vol.29 número2Una mirada al diagnóstico de laboratorio de las enfermedades autoinmunes índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

  • No hay articulos citadosCitado por SciELO

Links relacionados

  • No hay articulos similaresSimilares en SciELO

Compartir


Revista Cubana de Hematología, Inmunología y Hemoterapia

versión impresa ISSN 0864-0289

Resumen

LAVAUT SANCHEZ, Kalia  y  PAVON MORAN, Valia. Clonal evolution in chronic myeloid leukemia. Rev Cubana Hematol Inmunol Hemoter [online]. 2013, vol.29, n.2, pp.114-118. ISSN 0864-0289.

Clonal evolution in chronic myeloid leukemia is defined as the presence of a variety of additional, nonrandom chromosomal abnormalities besides the Philadelfia chromosome. It occurs in approximately 30 % of patients in accelerated phase and 80 % of patients in blastic phase. It is considered a criterion for accelerated phase. Although it is associated with a poor prognosis, its significance is controversial. It depends on the specific cytogenetic abnormality, its frequency in karyotype study, the association with other progression clinical and cytogenetic alterations, its relationship with the time of appearance during the course of the disease and the therapy used.

Palabras clave : clonal evolution; chronic myeloid leucemia; Philadelphia chromosome; imatinib.

        · resumen en Español     · texto en Español