SciELO - Scientific Electronic Library Online

 
vol.32 número1Comportamiento de las células asesinas naturales, las dendríticas y los macrófagos, en el embarazoFunción del sistema NADPH oxidasa en la formación de trampas extracelulares de los neutrófilos (NETs) índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

  • No hay articulos citadosCitado por SciELO

Links relacionados

  • No hay articulos similaresSimilares en SciELO

Compartir


Revista Cubana de Hematología, Inmunología y Hemoterapia

versión impresa ISSN 0864-0289versión On-line ISSN 1561-2996

Resumen

CASADO HERNANDEZ, Imilla et al. Cytotoxicity in vitro and potential of quinoid compounds as antitumor agents. Rev Cubana Hematol Inmunol Hemoter [online]. 2016, vol.32, n.1. ISSN 0864-0289.

The search and identification of new active compounds for cancer therapy has focused mainly on research of natural products and their synthetic analogs. This paper aims to systematize the knowledge of the molecular basis of the cytotoxic activity of the quinoid compounds and their use as an antitumor agent. A review was performed on original articles, experimental section, published in the 2004-2014 decade in some databases of the Virtual Health Library (VHL). Numerous studies have supported the ability of quinoid products inhibiting cell growth, based on their ability to damage DNA by oxidative stress and thus have a biorreductive interaction with other biomolecules. Furthermore, the power of cytotoxicity increases quinoid compounds alkylated with side chains attached to rings and quinone flavored motif. Experimental evidence suggests a promising future of these molecules as antitumor agents, based on their high selectivity and cytotoxicity against neoplastic cell lines.

Palabras clave : cancer; quinones; in vitro cytotoxic activity; oxidative stress; natural product; antitumoral agent.

        · resumen en Español     · texto en Español     · Español ( pdf )

 

Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons