My SciELO
Custom servicesServices on Demand
Journal
Article
Spanish (pdf)
Article in xml format
Article references
Send this article by e-mailIndicators
Cited by SciELO
Related links
Similars in
SciELO
Share
Permalink
Revista Cubana de Hematología, Inmunología y Hemoterapia
Print version ISSN 0864-0289On-line version ISSN 1561-2996
Abstract
SOLER NODA, Gilberto; ROMERO DIAZ, Yisenia and BENCOMO HERNANDEZ, Antonio. Platelet antibodies in cuban patients waiting for renal transplantation. Rev Cubana Hematol Inmunol Hemoter [online]. 2019, vol.35, n.1, e894. ISSN 0864-0289.
Introduction:
Platelet-specific antigens, known as human platelet antigens (HPA), are included within the spectrum of non-HLA histocompatibility antigens, because HPA antibodies participate in the rejection of transplantation, besides being a cause of the phenomenon of platelet refractoriness.
Objective:
To characterize antibodies against platelet-specific antigens in Cuban patients awaiting kidney transplantation.
Methods:
The technique “monoclonal antibodies immobilized platelets antigens" was applied to blood samples from 901 patients.
Results:
HPA antibodies were detected in 78 patients, which in 87.17 % recognized the antigens present in the GP-IIb / IIIa complex. These antibodies were in 78.2 % of the IgG class, in 11.53 % IgA and IgM in 46.15 %.
Conclusions:
HPA antibodies, mostly of the IgG class and directed to antigens present in the GP-IIb/IIIa complex, are common in Cuban patients awaiting kidney transplantation.
Keywords : human platelet antigens; HPA; anti-HPA antibodies; alloimmunization; platelet refractoriness; kidney transplantation.
