Abstract

LAVAUT SANCHEZ, Kalia; QUINTERO SIERRA, Yamile  and  HERNANDEZ AGUILAR, Norbelys. Philadelphia isochromosome in two patients with chronic myeloid leukemia. Rev Cubana Hematol Inmunol Hemoter [online]. 2019, vol.35, n.1, e960. ISSN 0864-0289.

The Philadelphia chromosome (Ph) is present in more than 90% of patients with chronic myeloid leukemia. An extra Ph chromosome is one of the secondary alterations commonly observed in clonal evolution and it could be as na additional derivative or anisochromosome of the derivative. It is na alteration acquired during the progression of the disease with prognostic implications. We present two cases with a diagnosis of chronic myeloid leukemia, Who showed resistance to treatment with imatinib mesylate. In both patients,the chromosomal study with G-band technique, show cell lines with two isochromosomes from the derivative of 22, 2ider(22)t(9; 22). The first case died in blast crisis and to the second after not responding to the first line treatment, was precribed nilotinib but the evolution was unsatisfactory. Secondary chromosomal alterations are associated with a negative impact on survival and the progression to accelerated phase and blast crisis of the disease.

Keywords : Philadelphia chromosome; derivative isochromosome; chronic myeloid leukemia; BCR/ABL1.

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