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Revista Cubana de Hematología, Inmunología y Hemoterapia

versión On-line ISSN 1561-2996


QUINTERO SIERRA, Yamilé et al. Essential thrombocythemia in adult patients: 10 years’ experience. Rev Cubana Hematol Inmunol Hemoter [online]. 2023, vol.39  Epub 01-Mayo-2023. ISSN 1561-2996.


Essential thrombocythemia is a chronic myeloproliferative neoplasm characterized by thrombocytosis maintained in peripheral blood and hyperplasia of mature megakaryocytes in bone marrow, with specific histological and molecular characteristics.


To characterize of adult patients with essential thrombocythemia in the Institute of Hematology and Immunology.


An observational, descriptive, longitudinal and retrospective study was conducted. The universe consisted of 40 adult patients diagnosed and treated with essential thrombocythemia at the Institute of Hematology and Immunology from January 2010 to January 2020. The data obtained were stored in a database made with the program SPSS v 25.0 for Windows, from which they were processed.


The average age at diagnosis was 52,2 years and a median of 51 years. 80% occurred in females and 62,5% of patients were white. 85% of the patients had platelet counts in therange between 450-1500 ( 109/L. An increase in the enzyme lactate dehydrogenase was observed in 52,1% of the cases, and the JAK2V617Fmutationaccountedfor 67,5%. The overall survival in years was 35,5 and the disease-free survival was 32.5 years.


Adult patients with essential thrombocythemia have significantly increased overall and disease-free survival, with low incidence of thrombotic events and first-line treatment was associated with stable hematological response of patients.

Palabras clave : essential thrombocythemia; survival.

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