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Revista Cubana de Hematología, Inmunología y Hemoterapia

versión On-line ISSN 1561-2996


LAVAUT SANCHEZ, Kalia  y  GONZALEZ GARCIA, Sheila. Genetic biomarkers of B-cell acute lymphoid leukemia. Rev Cubana Hematol Inmunol Hemoter [online]. 2023, vol.39  Epub 26-Jun-2023. ISSN 1561-2996.


Acute lymphoid leukemia is a proliferation and malignant transformation of lymphoid progenitor cells in the bone marrow, blood and extramedullary sites. It is the most common neoplasm in childhood; it constitutes 80% of all acute leukemias in children; and the most frequent of those that originate from the B cell lineage. From the genetic point of view, there are multiple molecular and chromosomal alterations.


To describe the genetic biomarkers of the disease and its prognostic implication.


A review of the literature in English and in Spanish was carried out, in the PubMed website and using the search engine of Google Scholar, for articles published in the last five years. We performed analysis and summary of the reviewed bibliography.


In acute lymphoid leukemia, multiple cytogenetic alterations are detected, such as translocation t(9;22), t(12;21), rearrangements in 11q23 that generate fusions genes as well as other chromosomal aberrations and gene mutation. This genetic spectrum involves genes that participate in the development of lymphoid cells and in the regulation of the cell cycle. Knowledge of its biology, based on the study of genetic alterations as predictive biomarkers, allows the stratification of Acute lymphoid leukemia and the application of more personalized treatments to avoid relapses.

Palabras clave : B-cell lymphoid leukemia; aneuploidies; translocations; mutations.

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