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Revista Cubana de Hematología, Inmunología y Hemoterapia

versión On-line ISSN 1561-2996


ROQUE GARCIA, Wilfredo et al. Hematological alterations in peripheral blood of patients with COVID-19. Rev Cubana Hematol Inmunol Hemoter [online]. 2023, vol.39  Epub 30-Jun-2023. ISSN 1561-2996.


The first cases of atypical pneumonia of unknown etiology were reported in Wuhan, China in December 2019. In January 2020 a new virus from Coronaviridae family was described as causal agent and was named SARS-COV-2.


To evaluate the clinical significance of numerical values of complete blood count (CBC) and morphologic changes on peripheral blood on patients with COVID-19.


A descriptive, observational, transversal study included patients with diagnosis of COVID-19 admitted in Freyre de Andrade Hospital in Havana, between June 1st and September 31st of 2022 was carried out. Patients were assigned to two groups according to their admission in intensive vigilance ward or intensive care unit. CBC test and peripheral blood smear were performed on admission day to evaluate the significance on clinical evolution.


Female sex predominated on intensive vigilance group (67,36 %) and male in intensive care group (63,26 %). Media of age was superior in intensive care group (67,83 years). Leukocytosis and low level of platelets count were significantly more common in more severe group followed by lymphopenia. The presence of big platelets, cytoplasmic vacuoles and toxic granules were more common in intensive care unit group.


The CBC and peripheral blood smear are useful tools to diagnose and predict clinical evolution and allow a better management of infection.

Palabras clave : COVID-19; peripheral blood; complete blood count; cell morphology.

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