Resumo

MENENDEZ CABEZAS, Arturo  e  FERNANDEZ-BRITTO RODRIGUEZ, José E. Metabolismo de la homocisteína y su relación con la aterosclerosis. Rev Cubana Invest Bioméd [online]. 1999, vol.18, n.3, pp.155-168. ISSN 0864-0300.

A review on the details of the metabolism of homocysteine, a sulfur-containing amino acid that is normally obtained from methionine during the accomplishment of its function as a donor of methyl groups was made. Its possible metabolic destinations are analyzed, particularly the remethylation and the transsulfuration, in which the coenzymatic forms of vitamins B_6, B₁₂ and folate are involved, as well as its oxidation with which homocystine and mixed disulphides including the so-called homocystein attached to protcin, which is the main form circulating in plasma and in other destinations described in literature, are originated. The methods for stimating its plasmatic concentration and its reference values are related. The possible cause of hyperhomocysteinemia and the physiopathological mechanisms that link this status to atherogenesis and that try to explain the proposed hyperhomocysteinemia- atherosclerosis relation established by the results of epidemiological and clinical studies during the last 30 years are analyzed.

Palavras-chave : HOMOCYSTEINE [metabolism]; ATHEROSCLEROSIS.

        · resumo em Espanhol     · texto em Espanhol     · Espanhol ( pdf )