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vol.18 número3Aterosclerosis, colesterol y pared arterial: algunas reflexionesEfectos del alcoholismo crónico sobre el hígado de ratas albinas adolescentes índice de autoresíndice de assuntospesquisa de artigos
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Revista Cubana de Investigaciones Biomédicas

versão impressa ISSN 0864-0300versão On-line ISSN 1561-3011

Resumo

FERNANDEZ-BRITTO, José E et al. Impacto del tabaquismo como factor de riesgo aterosclerótico en edades tempranas. Rev Cubana Invest Bioméd [online]. 1999, vol.18, n.3, pp.176-188. ISSN 0864-0300.

The impact of smoking as an atherogenic risk factor in dead patients aged 5-34 that underwent necropsy was studied. This multinational investigation was carried out by the World Health Organization and the International Federation of Cardiology Societies from 1986 to 1996. The Center for General Coordination of this research in Malmö, sent 966 left halves of thoracica-orta, 947 left-halves of the abdominal aorta and 959 right coronary arteries.The arteries came from ll countries located in 5 regions of the World Health Organization: America, Africa, Europe, Southeastern and Southwestern Asia. These arteries were processed by using the methodology proposed by the World Health Organization since 1957 for the application of the atherometric system (AS), a set of methods and procedures considered as ideal for the pathomorphologic and morphometric characterization of the atherosclerotic lesion. The population of autopsies was divided into 2 groups: smokers and non smokers. Data were processed by statistical descriptive, comparative and multivariate analyses. Among the most important conclusions are the following: the distribution of adipose strias and fibrous plaques in the 3 studied arteries, thoracic aorta, abdominal aorta and right coronary artery was greater in smokers than in non smokers. The transformation of adipose strias into fibrous plaques began earlier and with much more intensity among smokers. The ANOVA statistical analysis between smokers and non smokers had a great signification in the 3 arteries. The result of the ANOVA statistical analysis showed the importance of the adipose strias in the thoracic aorta and of these strias and the fibrous plaques in the right coronary artery. It was clearly proved in this research that smoking is a strong risk factor for atherosclerosis and, therefore, for its organic consequences, the cardiovascular diseases at early ages.

Palavras-chave : SMOKING [adverse effects]; ATHEROSCLEROSIS [etiology]; RISK FACTORS; AORTA, THORACIC [pathology]; AORTA, ABDOMINAL [pathology]; CORONARY VESSELS [pathology].

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