SciELO - Scientific Electronic Library Online

 
vol.19 número1Durabilidad de la respuesta inmune antihepatitis B en trabajadores de la salud peruanos con 6 años de vacunadosDurabilidad de la respuesta inmune contra el vhb en niños de un círculo infantil en Cuba índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

  • No hay articulos citadosCitado por SciELO

Links relacionados

  • No hay articulos similaresSimilares en SciELO

Compartir


Revista Cubana de Investigaciones Biomédicas

versión impresa ISSN 0864-0300versión On-line ISSN 1561-3011

Resumen

GONZALEZ GRIEGO, Antonio et al. Evaluación y control de un brote epidémico de hepatitis viral en escolares guineanos: Eficacia de heberbiovac HB. Rev Cubana Invest Bioméd [online]. 2000, vol.19, n.1, pp.59-75. ISSN 0864-0300.

Four hundred and forty eight serological samples were analyzed to find out the etiology of an acute hepatitis ourbreak among Guinean students who studied in Cuba. IgM antibodies to hepatitis A(anti-HAV IgM), antibodies to main protein of hepatitis C virus (antiHCV), hepatitis B surface antigen (HbsAg) and its antibody (anti-HbsAg) and antibodies to hepatitis Delta (anti-HDV) were all determined. One hundred and twenty four sera (27.67%) were found to be positive to HbsAg. The presence of antigen linked to viral replication in virus B infection (HbsAg) was determined in 86 HbsAg positive sera whereas total antibodies (IgG and IgM) to central hepatitis B virus protein (total anti HbcAG) was detected in 50 of these samples. Those students who did not have virus B infection markers were immunized with Cuban anti-hepatitis B vaccine using three 20mg doses through a schedule of 30 d interdosage. There was positivity neither to anti-HAV IgM nor tp anti-HCV. The quantification of HbsAg allows to classify 3 of the 14 students showing hepatitis symptoms as acute hepatic patients with good prognosis and the remaining 121 young people as chronic patients. Of the sera of 3 deceased peoplle from fulminant hepatitis, 2 were HbsAg positive and 1 anti-HbsAg positive and the average lifetime estimated for the antigen was 48h in these cases whereas the average antigen lifetime for those acute patients with good evolution was nearly 7d and that of the chronic was 60 days. In chronic hosts, high antigenemia was detected (59%, with HbsAg from 10 to 100 mg/mL) associated with HbcAg positive in 31% of sera B. Anti-HDV antibodies were found in 15% of HbsAg positive sera and in 66% of the dead people. The quantification of HbsAg allowed to establish predictive classification criteria of the infested people. The relationship of the presence of HbsAg in chronic hosts with hih levels of HbsAg showed the value of the quantification of surface antigen as an indirect indicator of infectivity. The circulation of Delta virus was deemed to be a contibuting factor to the emergence of the hepatitis outbreak and mortality. After mass vaccination of sensitive students, no new clinical case occured, seroprotection reached 98% of the immunized people; with geometric means of 1 398UI/L

Palabras clave : DISEASE OUTBREAKS [prevention and control]; HEPATITIS, VIRAL, HUMAN [epidemiology]; HEPATITIS, VIRAL, HUMAN [blood]; HEPATITIS B VACCINES; FELLOWSHIPS AND SCHOLARSHIPS; GUINEA.

        · resumen en Español     · texto en Español     · Español ( pdf )

 

Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons