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vol.19 número1Respuesta pos-vacunal y persistencia de anticuerpos contra el virus de la hepatitis B en niños asmáticos y no asmáticos vacunados con eberbiovac-HB índice de autoresíndice de materiabúsqueda de artículos
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Revista Cubana de Investigaciones Biomédicas

versión impresa ISSN 0864-0300versión On-line ISSN 1561-3011

Resumen

RAMIREZ, Victoria et al. Efectividad absoluta y relativa de la vacunación antihepatitis B en niños de Quillabamba, Perú, 1997-1999. Rev Cubana Invest Bioméd [online]. 2000, vol.19, n.1, pp.106-120. ISSN 0864-0300.

Knowing the importance that the Pan-American Health Organization gives to Hepatitis B as a health problem in some regions of South America and bearing in mind the recommendations of the commission in charge of the control of this hepatitis in Peru, the Ministry of Health in this country started a mass vaccination of under one year-old infants in highly and medium endemic areas. This paper sets forth a concurrent study of 115 children immunized with Heberbiovac HB (10 µg/dose, at 0, 2 and 4 months) which incorporated the Extended Immunization Program in Peru and 77 non-vaccinated children. All of them were serologically analyzed to find out prevalence of infection and of HBV carriers (HbsAg and anti-HbcAg) and their anti-HbsAG was quantified using immunoenzymatic methods of Organon Teknika. There was no evidence of virus B infection in the children accounting for 100 % effectiveness. The percentages of seroconversion, seroprotection and hyperesponse among the immunized children were 99.1, 98.3 and 42.6 respectively. Markers of previous infection were found in 31.1 % of children and 3.9 were HbsAg positive. Considering the average age at which markers occur and the levels of HbsAg, it was thought that a pattern of horizontal transmission predominates, which supports the study of people living in the same place as the infested subject and the assessment of non-evident route of infection. On the basis of the impact of vaccination, it was recommended to immunize all children in need of, even if they are not included in the age range set for the Extended Immunization Program as well as to people living with these children if viral spread is detected

Palabras clave : HEPATITIS B VACCINES [immunology]; HEPATITIS B SURFACE ANTIGENS [analysis]; MASS VACCINATION; VACCINES,SYNTHETIC; IMMUNIZATION SCHEDULE; PERU.

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