Resumo

SALDANA BERNABEU, Alberto; GARCIA TRIANA, Bárbara Elena; GARCIA PINEIRO, José Carlos  e  CAPOTE PEREIRA, Lázaro. El daño oxidativo en la vasculopatía postrasplante. Rev Cubana Invest Bioméd [online]. 2001, vol.20, n.3, pp.236-238. ISSN 0864-0300.

The chronic rejection has become a great challenge to long-term survival of solid organ transplantations. The generation of reactive oxygen species is a relevant consequence of all the phenomena considered as risk factors in this process. This is the reason why the determination of the possible pathogenic role of these chemical species in the vascular changes taking place in late graft failure is of great interest in the light of the present scientific knowledge. The main evidence that make possible to establish a close linking between oxidative damage and the mechanisms involved in intimal hyperplasia that functionally deteriorate transplanted organs in the long run are discussed

Palavras-chave : OXIDATIVE STRESS; FREE RADICALS; REACTIVE OXYGEN SPECIES; RISK FACTORS; VASCULAR DISEASES; GRAFT REJECTION [complications]; GRAFT REJECTION [physiopathology].

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