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Revista Cubana de Investigaciones Biomédicas

versão impressa ISSN 0864-0300versão On-line ISSN 1561-3011

Resumo

ROJO DOMINGUEZ, Delia; BELL HEREDIA, Luis; CANCIO MARTINEZ, Elena  e  IGLESIAS LORES, Roberto. Efecto del extracto hipoglicemiante de Petiveria alliacea L sobre el consumo de glucosa por los eritrocitos. Rev Cubana Invest Bioméd [online]. 2002, vol.21, n.3, pp.161-166. ISSN 0864-0300.

The effect of a hypoglycemic extract of Petiveria alleacea L on glucose consumption was studied by using the erythrocytes of voluntary healthy donors. The erythrocytes were incubated with a dilution of sheilina of 1 UD/10 mL during 4 hours and the glucose concentration was determined at 0, 30, 60, 90, 120, 150, 180, 210 and 240 min. To determine the existance of a dose response effect, the erythrocytes were incubated with increasing doses of sheilina (0, 0.5, 1, 5, 10 and 15 U/10 mL) It was observed that even at elevated doses sheilina does not affect the consumption of glucose by the erythrocytes. These results suggest that the action of the product affects neither the glucose tansporter (glut 1) nor the anaerobic phase of glycosis. That’s why its hypoglycemic action seems to be connected with insulin action.

Palavras-chave : PLANTS, MEDICINAL; PLANT, EXTRACTS [therapeutic use]; ERYTHROCITES [metabolism]; DIABETES MELLITUS [drug therapy]; DIABETES MELLITUS [drug effects]; HYPOGLYCEMIC AGENTS [therapeutic use].

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