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Revista Cubana de Investigaciones Biomédicas

versión impresa ISSN 0864-0300versión On-line ISSN 1561-3011

Resumen

ALBA ZAYAS, Lázaro E.; PEREIRA ROCA, Giovanna  y  AGUILAR BETANCOURT, Arístides. Lipoproteína (a): estructura, metabolismo, genética y mecanismos patogénicos. Rev Cubana Invest Bioméd [online]. 2003, vol.22, n.1. ISSN 0864-0300.

The most outstanding characteristics of lipoprotein (a) as well as the pathogenic mechansism of this lipoproteinic particle related to atherothrombogenesis are established. Liopoprotein (a) [Lp (a)] discovered by Kare Berg, in 1963, has a similar composition to that of low density lipoprotein (LDL). In its structure it also presents apolipoprotein (a) [apo (a)], which is bound to apo B100 by a disulfur bond. The most interesting aspect of the biology of Lp (a) is undoubtedly the surprising structural homology existing between plasminogen and apo (a). This apolipoprotein is also the responsible for the metabolic and biochemical properties of lipoprotein (a). Due to its peculiar structure and to the correlation existing between the elevated levels of Lp (a) and the development of atherothrombotic complications, this lipoprotein has become the object of numerous researches.

Palabras clave : LIPOPROTEIN (a) [metabolism]; LIPOPROTEIN (a) [genetics]; LIPOPROTEIN (A) [ultrastructure]; POLYMORPHISM (GENETICS); APO LIPOPROTEIN (A); ATHEROSCLEROSIS; RISK FACTORS.

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