Resumo

LOPEZ DIAZ-GUERRERO, Norma et al. Daño al ADN y niveles de radicales libres en fibroblastos de ratones jóvenes y viejos. Rev Cubana Invest Bioméd [online]. 2003, vol.22, n.2, pp.107-116. ISSN 0864-0300.

The ADN damage was evaluated in primary cultures of lung fibroblasts from young (2 months) and old (13 months) mice in the presence and absence of a challenge presented by oxidative stress. This damage was correlated with the levels of the reactive oxygen species to contribute to the understanding of the relation existing between the levels of reactive oxygen species and the damage caused by cellular aging to the genoma. This is a complex phenomenon that has been tried to explain by different ways. One of them is the theory of aging caused by free radicals, which proposes that this phenomenon results from the accumulation of the damage caused by the reactive oxygen species during the organism’s life. However, there are other theories that rule out the oxidative stress and try to explain aging on the basis of programmed changes occurring in the expression of certain genes.

Palavras-chave : CELL AGING; DNA DAMAGE; REACTIVE OXYGEN SPECIES; FREE RADICALS; OXIDATIVE STRESS; FIBROBLASTS; MICE.

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