SciELO - Scientific Electronic Library Online

 
vol.22 número4Inmunoglobulina intravenosa: sus aplicaciones índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

  • No hay articulos citadosCitado por SciELO

Links relacionados

  • No hay articulos similaresSimilares en SciELO

Compartir


Revista Cubana de Investigaciones Biomédicas

versión impresa ISSN 0864-0300versión On-line ISSN 1561-3011

Resumen

Rev Cubana Invest Bioméd [online]. 2003, vol.22, n.4, pp.253-258. ISSN 0864-0300.

The paper was aimed at determining the existence of a protective effect of alcohol on atherosclerosis, evaluating the possible effects of chronic ingestion and moderate doses of ethanol on the oxidative stress parameters and exploring the interaction between the efects of a hypercholesterolemic diet and of ethanol on the oxidative stress variables. For this purpose, 22 rabbits were used distributed into 4 groups: treated with alcohol, treated with hypercholesterolemic diet, with alcohol and diet and a control group. The variables superoxide dismutase (SOD), catalases (CAT) and malonil-dialdehyde (MDA) were analyzed. The animals treated with diet showed values of SOD,CAT and MDA significantly higher than those of the rabbits treated with alcohol and the control group. The rabbits under diet and ethanol showed CAT and MDA values that exceeded those observed in rabbits treated only with diet. It was concluded that chronic alcohol consumption, though at moderate dose, disturbs the anti-oxidation system, so we can not state that it has a protective effect against atherosclerosis and that the consumption of a cholesterol-rich diet increases lipid peroxidation and enzymes SOD and CAT.

Palabras clave : ALCOHOLISM; OXIDATIVE STRESS [drug effects]; ATERIOSCLEROSIS; SUPEROXIDE DISMUTASE; CATALASE; ETHANOL [metabolism]; DIET, ATHEROGENIC; HYPERCHOLESTEROLEMIA; RABBITS.

        · texto en Español     · Español ( pdf )

 

Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons