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Revista Cubana de Investigaciones Biomédicas

versão impressa ISSN 0864-0300versão On-line ISSN 1561-3011

Resumo

GRA MENENDEZ, Silvia  e  CRUZ-BUSTILLO CLARENS, Diana. Some genetic, molecular and clinical aspects of nonpolyposis hereditary colorectal cancer. Rev Cubana Invest Bioméd [online]. 2004, vol.23, n.1, pp.43-50. ISSN 0864-0300.

A review was made aimed at going deep into the knowledge about nonpolyposis hereditary cancer. Its historical evolution, as well as its genetic, molecular and clinical characteristics conditioning the clinical management of the patients with this affection and of the relatives at risk were stressed. The first reference to the hereditary character of colorectal cancer was made at the end of the last century. The current knowledge of its molecular base, clinical identification and genetic diagnosis are the result of the research carried out in this field since then. The nonpolyposis hereditary colorectal cancer is a pathology accounting for approximately 4 % of the total of colorectal cancer

Palavras-chave : COLORECTAL NEOPLAMS, HEREDITARY NONPOLYPOSIS [genetics]; COLORECTAL NEOPLAMS, HEREDITARY NONPOLYPOSIS [pathology]; MUTATION; RISK FACTORS; GENES, SUPPRESSOR.

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