Resumo

FERNANDEZ-BRITTO RODRIGUEZ, José Emilio et al. The early atherogenic signal: a multinational study of 4 934 children and youth and 1 278 autopsiesThe early atherogenic signal: a multinational study of 4 934 children and youth and 1 278 autopsies. Rev Cubana Invest Bioméd [online]. 2005, vol.24, n.3. ISSN 0864-0300.

The results of 5 researches conducted among children and youth were presented to prove that there exists a series of early atherogenic signals since the first ages of life that are possible to detect and that once known oblige to take some medical and sociocultural measures that allow to prevent or delay the development of atherosclerosis. Children and adolescents aged 5-6 from 6 schools of Havana City , 2 from Panama , 1 from Concepción , Chile , and 3 from Itapetininga , Brazil , were studied. The aorta and the right coronary artery from the autopsies of a multinational study directed by the World Health Organization were also investigated. 18 countries from 4 continents took part in this study, in which children and youth aged 5-34 were studied. All of them had had a violent death. The results of the pathomorphological and morphometric studies were presented by using the atherometric system. The impact of 3 risk factors, arterial hypertension, type 2 diabetes mellitus and smoking on the production of atherosclerotic lesions, was studied. The most relevant conclusions were: 1. There are enough early atherogenic signals, such as arterial hypertension, obesity, exaggerated hip circumference, altered body mass index, active and passive smoking and the family pathological history of suffering from some disease related to atherosclerosis. 2. As discriminatory elements for the identification of children and youth in the different countries, the most significant variables were body weight, hip circumference and the values of systolic and diastolic arterial pressure. 3. In the autopsy studies, it was proved the increase of intima areas occupied by atherosclerotic lesions with the progress of age and the great effect that hypertension , type 2 diabetes mellitus and smoking exert on the development of atherosclerosis and the transformation of the adipose striae into fibrous plaques

Palavras-chave : Atherosclerosis; early atherogenic signal (EAS); atherogenic risk factors; atherometric system; pathomorphology; morphometry.

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