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Revista Cubana de Investigaciones Biomédicas

versión impresa ISSN 0864-0300


MENDEZ ROSABAL, Annerys. J wave syndromes. Rev Cubana Invest Bioméd [online]. 2012, vol.31, n.2. ISSN 0864-0300.

A review was conducted of the newest and most controversial aspects of J wave syndromes, including early repolarization syndrome, idiopathic ventricular fibrillation and sudden unexplained nocturnal death. Emphasis is made on the ECG features of these syndromes, among them the presence of an upwardly concave ST irregularity with notching or slurring. A detailed analysis is made of genetic bases, which are sometimes common to all syndromes, particularly the SCN5A mutation, associated with the ST upwardly irregularity, and more recently the S422L-KCNJ8 mutation causing the alteration in the lK-ATP channels, associated with arrhythmic cardiac mortality. It is concluded that not all patients with this syndrome are at risk of arrhythmic events or sudden cardiac death, but a significant number of them are. Therefore, a great challenge for the medical community is to develop better risk stratification strategies as well as safer and more effective treatments.

Palabras clave : J wave; early repolarization.

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