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Revista Cubana de Investigaciones Biomédicas

versión impresa ISSN 0864-0300


CASTRO HEVIA, Jesús A. Update on the management of patients with the Brugada syndrome ECG pattern. Rev Cubana Invest Bioméd [online]. 2012, vol.31, n.2. ISSN 0864-0300.

The Brugada syndrome is a channelopathy causing between 4-12 % of all sudden cardiac deaths and 20 % in subjects with a "healthy heart". It is a clinical and electrocardiographic syndrome characterized by a convex electrocardiographic pattern in at least 2 right precordial leads as well a propensity to the occurrence of syncopes and/or cardiac arrest caused by polymorphic ventricular tachycardia and/or ventricular fibrillation. Malignant ventricular arrhythmias are caused by the transmural dispersion of repolarization and/or delayed conduction in the right ventricular outflow tract. It is more common in the male sex, frequently appearing in mid life. The risk of new events in symptomatic subjects is 30-40% in the 3 years following diagnosis. The treatment of choice is implantation of an automatic defibrillator. Quinidine has been used in patients with implanted defibrillators and frequent events of ventricular arrhythmia, as well as in those refusing to have such devices implanted. Management of asymptomatic subjects is under discussion. The database at the cardiac arrhythmia service of the Institute of Cardiology contains data for more than 80 patients with this syndrome, 45 with implanted automatic defibrillators.

Palabras clave : Brugada syndrome; automatic implantable defibrillator; ventricular tachycardia; ventricular fibrillation.

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