SciELO - Scientific Electronic Library Online

 
vol.34 número2El sistema antioxidante del glutatión en la etiopatología de la disfunción nigro-estriatal índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Journal

Artigo

Indicadores

  • Não possue artigos citadosCitado por SciELO

Links relacionados

  • Não possue artigos similaresSimilares em SciELO

Compartilhar


Revista Cubana de Investigaciones Biomédicas

versão impressa ISSN 0864-0300versão On-line ISSN 1561-3011

Resumo

RAMIREZ ESTEVA, Osmay Ediberto et al. Hepatic, pancreatic and alveolar repercussions of altered zinc and vitamin homeostasis in smoking and alcoholism. Rev Cubana Invest Bioméd [online]. 2015, vol.34, n.2, pp.187-203. ISSN 0864-0300.

The purpose of the study was to explain the association between altered homeostasis of zinc and some vitamins and its hepatic, pancreatic and alveolar repercussions in smokers and drinkers. These individuals bring into their bodies the toxic action of ethanol and tobacco smoke. The data obtained show that high alcohol intake causes hypozincemia (less than 10 µmol/L), resulting in hepatic dysfunction, with insufficient vitamin A and folic acid absorption; hepatic and pancreatic dysfunction, with low vitamin C bioavailability; and repression of collagenase enzyme expression. Excessive alcohol consumption and the continual inhalation of tobacco smoke resulted in displacement of zinc homeostasis toward severe hypozincemia (less than 5 µmol/L), alveolar dysfunction with repression of interleukin-10 expression and low vitamin C serological levels. Common pathological events associated with inflammatory processes of the liver, pancreas and alveoli were the excessive production of reactive oxygen species and the manifestation of oxidative stress.

Palavras-chave : zinc homeostasis; alcoholism; smoking; oxidative stress.

        · resumo em Espanhol     · texto em Espanhol     · Espanhol ( pdf )

 

Creative Commons License Todo o conteúdo deste periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons