SciELO - Scientific Electronic Library Online

 
vol.34 número3Progresión de plasmocitoma óseo a mieloma múltiple y reporte de un caso índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

  • No hay articulos citadosCitado por SciELO

Links relacionados

  • No hay articulos similaresSimilares en SciELO

Compartir


Revista Cubana de Investigaciones Biomédicas

versión impresa ISSN 0864-0300versión On-line ISSN 1561-3011

Resumen

GALAN MARTINEZ, Loipa; SOUTO CARDENAS, Rafael Damián; VALDES GARCIA, Suria  y  MINABERRIET CONCEIRO, Enrique. Transient receptor potential ion channels and their leading role in analgesic therapy. Rev Cubana Invest Bioméd [online]. 2015, vol.34, n.3. ISSN 0864-0300.

In the search for new therapeutic options for pain treatment, new ion channels have been discovered, which act as receptors and are present in primary afferent nociceptor neurons. Some of them are the transient receptor potential ion channels that regulate the pathways involved in pain and nociception. An updated review of the main transient potential receptors ion channels involved in pain physiopathology and a historical review of the discovery of these molecules and advanced studies on them were also made. Then the different families of these channels with their classification, nomenclature, structure and cell functions were also examined. An account of the relationships of these channels with analgesia as well as the mechanism of action of some analgesics acting upon them was also presented. Finally, important considerations were given, which should be taken into account since they might influence on the clinical use of these drugs. For these reasons, the paper intends to be a review covering the role of the transient receptor potential channels as new pharmacological targets in the pain treatment.

Palabras clave : transient receptor potential channels; pain; analgesia; analgesics; capsaicin.

        · resumen en Español     · texto en Español     · Español ( pdf )

 

Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons