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Revista Cubana de Investigaciones Biomédicas

Print version ISSN 0864-0300On-line version ISSN 1561-3011


RAMO ROBLEDO, Alejandro  and  DORTA CONTRERAS, Alberto Juan. Neuroimmunological diagnosis of eosinophilic meningoencephalitis caused by Angiostrongylus cantonensis. Rev Cubana Invest Bioméd [online]. 2019, vol.38, n.4, e302.  Epub Feb 28, 2020. ISSN 0864-0300.

Diagnosis of meningoencephalitis due to Angiostrongylus cantonensis is based on the presence of helminth larvae in cerebrospinal fluid, but such evidence is very hard to find, since the larvae are labile in this medium and cannot be spotted easily. Based on the fact that presence of the parasite in Cuba dates back to 1981, and this is the only agent of the disease in the country, a review was conducted with the purpose of going over the published literature about the topic and gather evidence leading to the auxiliary diagnosis of eosinophilic meningoencephalitis. The study of the intrathecal synthesis of IgE and C3c, alongside the local synthesis pattern for IgA+IgG mainly and IgG1+IgG2, are proposed as the most appropriate. Other useful proteins are the intrathecal synthesis of C4 and to a lesser extent MBL.

Keywords : eosinophilic meningoencephalitis; Angiostrongylus cantonensis; cerebrospinal fluid; diagnosis; IgA; IgG; IgG1; IgG2; C3c; C4; MBL.

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