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Revista Cubana de Investigaciones Biomédicas
Print version ISSN 0864-0300On-line version ISSN 1561-3011
Abstract
RODRIGUEZ-GUZMAN, Roger; CESPEDES MIRANDA, Ela María and SUAREZ CASTILLO, Niurelkis. Uric acid and gamma-glutamyltransferase as biomarkers of cardiovascular disease via oxidative stress. Rev Cubana Invest Bioméd [online]. 2020, vol.39, n.4, e528. Epub Jan 01, 2021. ISSN 0864-0300.
Introduction:
Cardiovascular diseases are the leading cause of mortality and morbidity worldwide. Recognized as a health problem of social impact; they have prompted many scientists to try to explain their pathogenesis. New risk factors are currently acknowledged alongside the classic ones. These factors include the role of high uric acid concentrations and the activity of the enzyme gamma-glutamyltransferase in blood, both of which are biomarkers of oxidative stress. These elements may individually contribute to the development of cardiovascular diseases, and seem to have a synergistic effect.
Objective:
Review the evidence supporting the idea that high uric acid concentrations and the activity of the enzyme gamma-glutamyltransferase in blood may be risk factors contributing to the development of cardiovascular diseases via oxidative stress.
Methods:
Data were collected from the databases of various search engines (Medline-Pubmed, Cochrane, Scopus and SciELO) from 1 March 2019 to 23 May 2020.
Conclusions:
It was found that uric acid and gamma-glutamyltransferase are hormetic products causing an antioxidant effect on the organism at low concentrations. However, when concentrations rise, they are involved in the occurrence of oxidative processes leading to endothelial dysfunction and cardiovascular diseases.
Keywords : oxidative stress; uric acid; gamma-glutamyltransferase; cardiovascular disease.