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Nucleus

versión impresa ISSN 0864-084X

Resumen

LEYVA MONTANA, René; PERERA, Alejandro  y  MORIN ZORRILLA, José A.. Radiopharmaceuticals in immunoscintigraphy and radioimmunotherapy. Nucleus [online]. 2012, n.52, pp.68-72. ISSN 0864-084X.

The high morbidity-mortality of cancer makes   this condition in Cuba, and at international level, a serious health problem. Radioimmunodiagnosis and radioimmunotherapy based in the growing biotechnological advances, and the actual knowledge of molecular and cellular biology, become a highly promising tools in the fight against cancer. In this work we present a brief review of the radiopharmaceuticals developed in our country starting from biomolecules produced en Cuba, as well as a panoramic of several monoclonal antibodies and radionuclides used in clinical applications. Radioimmunodiagnosis applications are based on murine monoclonal antibodies, produced in form of lyophilized kits for http://img/revistas/nuc/n52/img/e02135212.jpglabeling. We also examined the perspectives of the application of radioimmunotherapy in Cuba starting from the international experiences, particularly in non-Hodgkin’s lymphoma treatment, keeping in mind the availability of different monoclonal antibodies already humanized, as well as of http://img/revistas/nuc/n52/img/e01135212.jpgfrom the existing   technologies in Cuban research-production centers.

Palabras clave : radiopharmaceuticals; monoclonal antibodies; radioinmunotheraphy; radioinmunoescintighrapy; labelling.

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