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Print version ISSN 0864-084XOn-line version ISSN 2075-5635


PRATS CAPOTE, Anaís; LEYVA MONTANA, René; ATIES PEREZ, Regla Caridad  and  PERERA PINTADO, Alejandro. Nuclear imaging with radiolabeled monoclonal antibodies: old applications with new aproaches. Nucleus [online]. 2020, n.67, pp.22-27.  Epub July 23, 2020. ISSN 0864-084X.

In the beginning, radionuclide-labeled monoclonal antibodies were widely employed for the study of various diseases, mainly oncological, by immunoscintigraphy. They were gradually replaced by molecules with better performance such as peptides and 18F-FDG. However, in the present century, the wide introduction of immunotherapy produced a paradigm shift in the use of radiolabeled monoclonal antibodies for the proper selection and follow-up of patients to be treated with immunotherapy, re-emerging of the immune-single photon emission tomography (immuno-SPECT), the immune-positron emission tomography (immuno-PET) and the co-registered image with computed tomography (CT) as imaging modalities of great value in the management of cancer. The aim of the present work was to provide an overview of the evolution of nuclear imaging with radiolabeled monoclonal antibodies and their main applications over the time, mainly in the study of patients with cancer.

Keywords : radioimmunoassay; antigens; antibodies; single photon emission computed tomography; positron computed tomography; monoclonal antibodies; radioimmunoscintigraphy.

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