SciELO - Scientific Electronic Library Online

 
 número6725 años de CENTIS. Pandemia y RadiofármacosEstudio por fluorescencia de rayos x de la polucion por metales pesados en sedimentos de la subcuenca Mamposton (Mayabeque, Cuba) índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

  • No hay articulos citadosCitado por SciELO

Links relacionados

  • No hay articulos similaresSimilares en SciELO

Compartir


Nucleus

versión impresa ISSN 0864-084Xversión On-line ISSN 2075-5635

Resumen

PRATS CAPOTE, Anaís; LEYVA MONTANA, René; ATIES PEREZ, Regla Caridad  y  PERERA PINTADO, Alejandro. Nuclear imaging with radiolabeled monoclonal antibodies: old applications with new aproaches. Nucleus [online]. 2020, n.67, pp.22-27.  Epub 23-Jul-2020. ISSN 0864-084X.

In the beginning, radionuclide-labeled monoclonal antibodies were widely employed for the study of various diseases, mainly oncological, by immunoscintigraphy. They were gradually replaced by molecules with better performance such as peptides and 18F-FDG. However, in the present century, the wide introduction of immunotherapy produced a paradigm shift in the use of radiolabeled monoclonal antibodies for the proper selection and follow-up of patients to be treated with immunotherapy, re-emerging of the immune-single photon emission tomography (immuno-SPECT), the immune-positron emission tomography (immuno-PET) and the co-registered image with computed tomography (CT) as imaging modalities of great value in the management of cancer. The aim of the present work was to provide an overview of the evolution of nuclear imaging with radiolabeled monoclonal antibodies and their main applications over the time, mainly in the study of patients with cancer.

Palabras clave : radioimmunoassay; antigens; antibodies; single photon emission computed tomography; positron computed tomography; monoclonal antibodies; radioimmunoscintigraphy.

        · resumen en Español     · texto en Español     · Español ( pdf )