Resumo

TORRES LIMA, Virginia; TORRES LIMA, Ana María; HERNANDEZ CUELLAR, María Victoria  e  AMARO RELOVA, Roberto. Inmunopatogenia de la artritis reumatoidea: Conceptos actuales. Rev Cubana Med Gen Integr [online]. 1998, vol.14, n.5, pp. 429-433. ISSN 1561-3038.

It is reported that rheumatoid arthritis is a systemic autoinmune inflammatory disease whose causes are yet unelear but several factors are supposed to be important in its pathogenesis such as environmental factors and genetic factors (linked to the main histocompatibility complex and to coding genes for the synthesis of inmunoglobulin, T-cell receptors, cytokines and adhesive molecules). When these factors interact, they mediate the articular damage inherent to the disease where inmune response events also participate. Additionally, other mechanisms of articular damage by oncogene priming are presented. They regulate both apoptosis and proteolytic enzime priming contributing to pannus formation

Palavras-chave : ARTHRITIS RHEUMATOID [inmunology]; ARTHRITIS, RHEUMATOID [genetics].

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