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Revista Cubana de Medicina General Integral

Print version ISSN 0864-2125On-line version ISSN 1561-3038


PEREZ MARTINEZ, Víctor T.. Dementia in Alzheimer's disease: a comprehensive approach. Rev Cubana Med Gen Integr [online]. 2005, vol.21, n.3-4. ISSN 0864-2125.

The pathological substrate of the main dementia is composed of the following lesions: the diffuse and abundant neurofibrillar degeneration, the neuritic plaques and the abnormal deposit of amyloid substance in the brain, causing cerebral toxicity. Dementia in Alzheimer's disease accomplishes a clinicotopographic pattern of characteristic cortical type. Its definitive diagnosis is anatomopathological, but a probable diagnosis based on the clinic and the neuropsychological evaluation can be established. There is no a concluding effective treatment for the cognitive deterioration of Alzheimer's disease.

Keywords : Neurofibrillar; neuritic; amyloid; cortical; anatomopathological; cognitive.

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